CHEM 253 - Antibiotics
The course focuses on the discovery and development of modern antibiotics. We will discuss the discovery, synthesis, medicinal chemistry, mechanism of action studies, and preclinical as well as clinical development of drugs that are currently being used in the therapy of bacterial infections. Emphasis will be given to compounds approved over the last three decades and investigational drugs that are in clinical trials.
The first part of the course introduces general aspects of the drug discovery and development process including examples from the antibiotics field. The optimization and preclinical development of antibiotics serve as models to illustrate the integration of medicinal chemistry in the drug discovery process. In the second part of the course, individual classes of antibiotics, their discovery, synthesis, mechanism of action and clinical application will be discussed.
Syllabus - Lecture 1
Lecture 2
Lecture 3
Lecture 4
Lecture 5
Lecture 6
Lecture 7
Lecture 8
Lecture 9
Lecture 10