Hepatitis C virus NS5B polymerase inhibitor

1-Cyclohexyl-2-(furan-3-yl)-1H-benzo[d]imidazole-5-carboxylic acid (2009) Dibrov SM, Dutta S & Hermann T. Acta Cryst. E 65, o2136. (PDF)

New cyanamide-induced ring expansion rearrangement of epoxy-lactams

1,3-Diazepanes of natural product-like complexity from cyanamide-induced rearrangement of epoxy-delta-lactams (2010) Dutta S, Higginson CJ, Ho BT, Rynearson KD, Dibrov SM & Hermann T. Org. Lett. 12, 360-363. (PDF)

HCV RNA-binding ligands based on the 3,5-diaminopiperidine scaffold

A modular approach to synthetic RNA binders of the hepatitis C virus internal ribosome entry site (2010) Carnevali M, Parsons J, Wyles DL & Hermann T. ChemBioChem 11, 1364-1367. (PDF

Antiviral compounds for the treatment of HCV infection (2009) Hermann T, Carnevali M. WO 2009/099897 A1. (PDF))

Dihydroxyoxolane rigid building block for RNA binding ligands

(3,4-Dihydroxyoxolan-2-yl)methyl 4-methylbenzenesulfonate (2010) Dibrov SM, Carnevali M & Hermann T. Acta Cryst. E 66, o3088. (PDF)

Imidazolinone scaffold for RNA binding ligands

A crystallographic study of a highly substituted imidazolinone, (3S,4S,5R)-3-(((S)-4-((1H-indol-3-yl)methyl)-5-oxo-4,5-dihydro-1H-imidazol-2-yl)amino)-4-((tert-butyldimethylsilyl)oxy)-5-hydroxypiperidin-2-one (2011) Dutta S, Dibrov SM, Higginson CJ & Hermann T. J. Chem.Cryst. 41, 1573-1578. (PDF)

New synthetic route to benzimidazole HCV translation inhibitors targeting the IRES RNA

An efficient new route to dihydropyranobenzimidazole inhibitors of HCV replication (2011) Parker MA, Satkiewicz E, Hermann T & Bergdahl BM. Molecules 16, 281-290. (PDF)

New heterocycle as rigid scaffold for RNA binding ligands

Synthesis and crystal structure of a novel heterocycle, 2-oxa-4,7-diazabicyclo[3.3.1]non-3-ene (2012) Dutta S, Dibrov SM, Ho BT, Higginson CJ & Hermann T. J. Chem.Cryst. 42, 119-129. (PDF)

Indole and isatine hydrazones targeting HCV translation

Antiviral translation inhibitors (2011) Hermann T, Carnevali M. PCT US61/567,968.

Oxazole analogs of streptolidine lactam as scaffolds for RNA-targeting ligands

Synthesis of oxazole analogs of streptolidine lactam (2013) Rynearson KD, Dutta S, Tran K, Dibrov SM & Hermann T. Eur. J. Org. Chem., 7337-7342.

2-Aminobenzoxazoles targeting the HCV internal ribosome entry site

2-Aminobenzoxazole ligands of the hepatitis C virus internal ribosome entry site (2014) Rynearson KD, Charrette B, Gabriel C, Moreno J, Boerneke MA, Dibrov SM & Hermann T. Bioorg. Med. Chem. Lett. 24, 3521-3525.

N1-Aryl-substituited benzimidazoles targeting the HCV internal ribosome entry site

Aryl-substituted aminobenzimidazoles targeting the hepatitis C virus internal ribosome entry site (2014) Ding K, Wang A, Boerneke MA, Dibrov SM & Hermann T. Bioorg. Med. Chem. Lett. 24, 3113-3117.

Spiro-cyclopropyl quinazoline targeting an RNA conformational switch in the HCV internal ribosome entry site

Ligand optimization by improving shape complementarity at a hepatitis C virus RNA target (2016) Charrette BP, Boerneke MA, & Hermann T. ACS Chem. Biol. in press.