Research Articles:

 

2017

Structure of the ribosomal decoding site RNA containing a Se-modified responsive fluorescent ribonucleoside probe (2017) Nuthanakanti A, Boerneke MA, Hermann T* & Srivatsan SG*.Angew. Chem. Int. Ed., in press.

2016

Ligand optimization by improving shape complementarity at a hepatitis C virus RNA target (2016) Charrette BP, Boerneke MA & Hermann T. ACS Chem. Biol. 11, 3263-3267.(PDF)

Crystal structure-guided design of self-assembling RNA nanotriangles (2016) Boerneke MA, Dibrov SM & Hermann T. Angew. Chem. Int. Ed. 55, 4097-4100.(PDF)

Structure of the HCV internal ribosome entry site subdomain IIa RNA in complex with a viral translation inhibitor (2016) Dibrov SM & Hermann T. Methods Mol. Biol.1320, 329-335. (PDF)

2015

Conformational flexibility of viral RNA switches studied by FRET (2015) Boerneke MA & Hermann T. Methods 91, 35-39. (PDF)

Ligand-responsive RNA mechanical switches (2015) Boerneke MA & Hermann T. RNA Biology 12, 780-786.(PDF)

2014

Analysis of mRNA recognition by human thymidylate synthase (2014) Brunn ND, Dibrov SM, Kao MB, Ghassemian M & Hermann T. Biosci. Rep. 34, 905-913. (PDF)

Functional conservation despite structural divergence in ligand responsive RNA switches (2014) Boerneke MA, Dibrov SM, Gu J, Wyles DL & Hermann T. Proc. Natl. Acad. Sci. USA 111,15952-15957. (PDF)

Nanopore-based conformational analysis of a viral RNA drug target (2014) Shasha C, Henley RY, Stoloff DH, Rynearson KD, Hermann T & Wanunu M. ACS Nano 8, 6425-6430. (PDF)

2-Aminobenzoxazole ligands of the hepatitis C virus internal ribosome entry site (2014) Rynearson KD, Charrette B, Gabriel C, Moreno J, Boerneke MA, Dibrov SM & Hermann T. Bioorg. Med. Chem. Lett. 24, 3521-3525. (PDF)

Aryl-substituted aminobenzimidazoles targeting the hepatitis C virus internal ribosome entry site (2014) Ding K, Wang A, Boerneke MA, Dibrov SM & Hermann T. Bioorg. Med. Chem. Lett. 24, 3113-3117. (PDF)

2013

Synthesis of oxazole analogs of streptolidine lactam (2013) Rynearson KD, Dutta S, Tran K, Dibrov SM & Hermann T. Eur. J. Org Chem., 7337-7342. (PDF)

Synthesis and crystal structure of a phenazine N-oxide (2013) Ding K, Dibrov SM & Hermann T. J. Chem.Cryst. 43, 550-553. (PDF)

Crystal structure of a benzimidazole hepatitis C virus inhibitor free and in complex with the viral RNA target (2013) Dibrov SM, Parker MA, Bergdahl BM & Hermann T. J. Chem.Cryst. 43, 235-239. (PDF)

Screening for inhibitors of the hepatitis C virus internal ribosome entry site RNA (2013) Zhou S, Rynearson KD, Ding K, Brunn ND & Hermann T. Bioorg. Med. Chem. 21, 6139-6144. (PDF)

Correcting pervasive errors in RNA crystallography through enumerative structure prediction (2013) Chou FC, Sripakdeevong, Dibrov SM, Hermann T & Das R. Nature Methods 10, 74-76. (PDF)

2012

 

Targeting a regulatory element in human thymidylate synthase mRNA (2012) Brunn ND, Garcia Sega E, Kao MB & Hermann T. ChemBioChem 13, 2738-2744. (PDF)

 

Structure of a hepatitis C virus RNA domain in complex with a translation inhibitor reveals a binding mode reminiscent of riboswitches (2012) Dibrov SM, Ding K, Brunn ND, Parker MA, Bergdahl BM, Wyles DL & Hermann T. Proc. Natl. Acad. Sci. USA 109, 5223-5228. (PDF)

 

RNA-Puzzles: A CASP-like evaluation of RNA three-dimensional structure prediction (2012) Cruz JA et. al. RNA 18, 610-625. (PDF)

 

Synthesis and crystal structure of a novel heterocycle, 2-oxa-4,7-diazabicyclo[3.3.1]non-3-ene (2012) Dutta S, Dibrov SM, Ho BT, Higginson CJ & Hermann T. J. Chem.Cryst. 42, 119-129. (PDF)

 

2011

A crystallographic study of a highly substituted imidazolinone, (3S,4S,5R)-3-(((S)-4-((1H-indol-3-yl)methyl)-5-oxo-4,5-dihydro-1H-imidazol-2-yl)amino)-4-((tert-butyldimethylsilyl)oxy)-5-hydroxypiperidin-2-one (2011) Dutta S, Dibrov SM, Higginson CJ & Hermann T. J. Chem.Cryst. 41, 1573-1578. (PDF)

Self-assembling RNA square (2011) Dibrov SM, McLean J, Parsons J & Hermann T. Proc. Natl. Acad. Sci. USA 108, 6405-6408. (PDF)

Structure of an RNA dimer of a regulatory element from human thymidylate synthase mRNA (2011) Dibrov SM, McLean JE & Hermann T. Acta Cryst. D 67, 97-104. (PDF)

An efficient new route to dihydropyranobenzimidazole inhibitors of HCV replication (2011) Parker MA, Satkiewicz E, Hermann T & Bergdahl BM. Molecules 16, 281-290. (PDF)

2010

(3,4-Dihydroxyoxolan-2-yl)methyl 4-methylbenzenesulfonate (2010) Dibrov SM, Carnevali M & Hermann T. Acta Cryst. E 66, o3088. (PDF)

A modular approach to synthetic RNA binders of the hepatitis C virus internal ribosome entry site (2010) Carnevali M, Parsons J, Wyles DL & Hermann T. ChemBioChem 11, 1364-1367. (PDF)

A model for the study of ligand binding to the ribosomal RNA helix h44 (2010) Dibrov SM, Parsons J & Hermann T. Nucleic Acids Res. 38, 4458-4465. (PDF)

1,3-Diazepanes of natural product-like complexity from cyanamide-induced rearrangement of epoxy-delta-lactams (2010) Dutta S, Higginson CJ, Ho BT, Rynearson KD, Dibrov SM & Hermann T. Org. Lett. 12, 360-363. (PDF)

2009

1-Cyclohexyl-2-(furan-3-yl)-1H-benzo[d]imidazole-5-carboxylic acid (2009) Dibrov SM, Dutta S & Hermann T. Acta Cryst. E 65, o2136. (PDF)

Conformational inhibition of the HCV IRES RNA (2009) Parsons J, Castaldi MP, Dutta S, Dibrov SM, Wyles DL & Hermann T. Nature Chem. Biol. 5, 823-825. (PDF) News and Views by DW Begley & G Varani: (PDF)

2008

Antibacterial activity in serum of the 3,5-diamino-piperidine translation inhibitors (2008) Zhou Y, Chow C, Murphy DE, Sun Z, Bertolini T, Froelich JM, Webber SE, Hermann T & Wall D. Bioorg. Med. Chem. Lett. 18, 3369-3375. (PDF)

Structure of hepatitis C virus IRES subdomain IIa (2008) Zhao Q, Han Q, Kissinger CR, Hermann T & Thompson PA. Acta Cryst. D 64, 436-443. (PDF)

Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'l6-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 2: Variation of the 2- and 6-pyridazinone substituents (2008) Zhou Y, Li LS, Dragovich PS, Murphy DE, Tran CV, Ruebsam F, Webber SE, Shah AM, Tsan M, Averill A, Showalter RE, Patel R, Han Q, Zhao Q, Hermann T, Kissinger CR, LeBrun L & Sergeeva MV. Bioorg. Med. Chem. Lett. 18, 1419-1424. (PDF)

Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'l6-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 1: Exploration of 7'-substitution of benzothiadiazine (2008) Zhou Y, Webber SE, Murphy DE, Li, LS, Dragovich PS, Tran CV, Sun Z, Ruebsam F, Shah AM, Tsan M, Showalter RE, Patel R, Li B, Zhao Q, Han Q, Hermann T, Kissinger CR, LeBrun L, Sergeeva MV & Kirkovsky L. Bioorg. Med. Chem. Lett. 18, 1413-1418. (PDF)

2007

Defining the molecular forces that determine the impact of neomycin on bacterial protein synthesis: importance of the 2-amino functionality (2007) Barbieri CM, Kaul M, Bozza-Hingos M, Zhao F, Tor Y, Hermann T & Pilch DS. Antimicrob. Agents Chemother. 51, 1760-1769. (PDF)

Conformational flexibility of ribosomal decoding-site RNA monitored by fluorescent pteridine base analogs (2007) Parsons J & Hermann T. Tetrahedron 63, 3548-3552. (PDF)

Apramycin recognition by the human ribosomal decoding site (2007) Hermann T, Tereshko V, Skripkin E & Patel DJ. Blood Cells Mol. Dis. 38, 193-198. (PDF)

Functional architecture of HCV IRES domain II stabilized by divalent metal ion in the crystal and in solution (2007) Dibrov SM, Johnston-Cox H, Weng YH & Hermann T. Angew. Chem. Int. Ed. 46, 226-229. (PDF)

Synthesis and SAR of 3,5-diamino-piperidine derivatives: novel antibacterial translation inhibitors as aminoglycoside mimetics (2007) Zhou Y, Gregor VE, Ayida BK, Winters GC, Sun Z, Murphy D, Haley G, Bailey D, Froelich JM, Fish S, Webber SE, Hermann T & Wall D. Bioorg. Med. Chem. Lett. 17, 1206-1210 (PDF)

2006

Structure-activity relationships of novel antibacterial translation inhibitors: 3,5-diamino-piperidinyl triazines (2006) Zhou Y, Sun Z, Froelich JM, Hermann T & Wall D. Bioorg. Med. Chem. Lett. 16, 5451-5456. (PDF)

2005

Structure-guided discovery of novel aminoglycoside mimetics as antibacterial translation inhibitors (2005) Zhou Y, Gregor VE, Sun Z, Ayida BK, Winters GC, Murphy D, Simonsen KB, Vourloumis D, Fish S, Froelich JM, Wall D & Hermann T. Antimicrob. Agents Chemother. 49, 4942-4949. (PDF)

Molecular recognition of RNA by neomycin and a restricted neomycin derivative (2005) Zhao F, Zhao Q, Blount KF, Han Q, Tor Y & Hermann T. Angew. Chem. Int. Ed. 44, 5329-5334. (PDF)

Conformational constraint as a means for understanding RNA-aminoglycoside specificity (2005) Blount KF, Zhao F, Hermann T & Tor Y. J. Am. Chem. Soc. 127, 9818-9829. (PDF)

Synthesis of dehydroalanine fragments as thiostrepton side chain mimetics (2005) Ayida BK, Simonsen KB, Vourloumis D & Hermann T. Bioorg. Med. Chem. Lett.15, 2457-2460. (PDF)

Molecular recognition by glycoside pseudo base pairs and triples in an apramycin-RNA complex (2005) Han Q, Zhao Q, Fish S, Simonsen KB, Vourloumis D, Froelich JM, Wall D & Hermann T. Angew. Chem. Int. Ed. 44, 2694-2700. (PDF)

Aminoglycoside-hybrid ligands targeting the ribosomal decoding site (2005) Vourloumis D, Winters GC, Simonsen KB, Takahashi M, Ayida BK, Shandrick S, Zhao Q, Han Q & Hermann T. ChemBioChem 6, 58-65. (PDF)

2004

Monitoring molecular recognition of the ribosomal decoding site (2004) Shandrick S, Zhao Q, Han Q, Ayida BK, Takahashi M, Winters GC, Simonsen KB, Vourloumis D, & Hermann T. Angew. Chem. Int. Ed. 43, 3177-3182. (PDF)

Rational design of azepane-glycoside antibiotics targeting the bacterial ribosome (2004) Barluenga S, Simonsen KB, Littlefield, ES, Ayida BK, Vourloumis D, Winters GC, Takahashi M, Shandrick S, Zhao Q, Han Q & Hermann T. Bioorg. Med. Chem. Lett. 14, 713-718. (PDF)

2003

Piperidine-glycosides targeting the ribosomal decoding site (2003) Simonsen KB, Ayida BK, Vourloumis D, Winters GC, Takahashi M, Shandrick S, Zhao Q & Hermann T. ChemBioChem 4, 886-890. (PDF)

Novel acyclic deoxystreptamine mimetics targeting the ribosomal decoding site (2003) Vourloumis D, Winters GC, Takahashi M, Simonsen KB, Ayida BK, Shandrick S, Zhao Q & Hermann T. ChemBioChem 4, 879-885. (PDF)

Solid-phase synthesis of benzimidazole libraries biased for RNA targets (2003) Vourloumis D, Takahashi M, Simonsen KB, Ayida BK, Barluenga S, Winters GC & Hermann T. Tetrahedron Lett. 44, 2807-2811. (PDF)

Carnitine palmitoyltransferase II deficiency: molecular and biochemical analysis of 32 patients (2003) Wieser T, Deschauer M, Olek K, Hermann T & Zierz S. Neurology 60, 1351-1353. (PDF)

2002

Novel 2,5-dideoxystreptamine derivatives targeting the ribosomal decoding site RNA (2002) Vourloumis D, Takahashi M, Winters GC, Simonsen KB, Ayida BK, Barluenga S, Qamar S, Shandrick S, Zhao Q & Hermann T. Bioorg. Med. Chem. Lett. 12, 3367-3372. (PDF)

Novel paromamine derivatives exploring shallow groove recognition of ribosomal decoding site RNA (2002) Simonsen KB, Ayida BK, Vourloumis D, Takahashi M, Winters GC, Barluenga S, Qamar S, Shandrick S, Zhao Q & Hermann T. ChemBioChem 3, 1223-1228. (PDF)

Brownian-Dynamics simulations of metal-ion binding to four-way junctions (2002) van Buuren BNM, Hermann T, Wijmenga SS & Westhof E. Nucleic Acids Res. 30, 507-514. (PDF)

2001

The mouse hypomorph allele Pax64Neu is a missense mutation affecting homeodomain structure and DNA binding activity (2001) Favor J, Peters H, Hermann T, Chatterjee B, Neuhauser-Klaus A & Sandulache R. Genetics 159, 1689-1700. (PDF)

Peptide-triggered conformational switch in HIV-1 RRE RNA complexes (2001) Gosser Y, Hermann T, Majumdar A, Hu W, Frederick R, Jiang F, Xu W & Patel DJ. Nature Struct. Biol. 8, 146-150. (PDF)

2000

A dimeric DNA interface stabilized by stacked A.(G.G.G.G).A hexads and coordinated monovalent cations (2000) Kettani A, Gorin A, Majumdar A, Hermann T, Skripkin E, Zhao H, Jones R & Patel DJ. J. Mol. Biol. 297, 627-644. (PDF)

1999

Aphid transmission of cauliflower mosaic virus requires the viral PIII protein (1999) Leh V, Jacquot E, Geldreich A, Hermann T, Leclerc, D., Cerutti, M., Yot P, Keller M & Blanc S. EMBO J. 18, 7077-7085. (PDF)

Dimerization of HIV-1 genomic RNA of subtypes A and B: RNA loop structure and magnesium binding (1999) Jossinet F, Paillart JC, Westhof E, Hermann T, Skripkin E, Lodmell JS, Ehresmann C, Ehresmann B & Marquet R. RNA 5, 1222-1234. (PDF)

Simulations of the dynamics at an RNA-protein interface (1999) Hermann T & Westhof E. Nature Struct. Biol. 6, 540-544. (PDF)

Docking of cationic antibiotics to negatively charged pockets in RNA folds (1999) Hermann T & Westhof E. J. Med. Chem. 42, 1250-1261. (PDF)

Mixed reconstitution of mutated subunits of HIV-1 revrese transcriptase coexpressed in Escherichia coli - two tags tie it up (1999) Maier G, Dietrich U, Panhans B, Schroder B, Rubsamen-Waigmann H, Cellai L, Hermann T & Heumann H. Eur. J. Biochem. 261, 10-18. (PDF)

1998

Exploration of metal ion binding sites in RNA folds by Brownian-dynamics simulations (1998) Hermann T & Westhof E. Structure 6, 1303-1314. (PDF)

The transcriptional activator GvpE for the halobacterial gas vesicle genes resembles a basic region leucine-zipper regulatory protein (1998) Kruger K, Hermann T, Armbruster V & Pfeifer F. J. Mol. Biol. 279, 761-771. (PDF)

Aminoglycoside binding to the hammerhead ribozyme: a general model for the interaction of cationic antibiotics with RNA (1998) Hermann T & Westhof E. J. Mol. Biol. 276, 903-912. (PDF)

Molecular dynamics investigations of hammerhead ribozyme RNA (1998) Hermann T, Auffinger P & Westhof E. Eur. Biophys. J. 27, 153-165. (PDF)

Structural changes of the Escherichia coli GroEL-GroES chaperonins upon complex formation: a neutron small angle scattering study (1998) Stegmann R, Manakova E, Rossle M, Heumann H, Nieba-Axmann SE, Pl´┐Żckthun A., Hermann T, May RP & Wiedenmann A. J. Struct. Biol. 121, 30-40. (PDF)

1997

Isoalloxazine derivatives promote photocleavage of natural RNAs at G.U pairs embedded within helices (1997) Burgstaller P, Hermann T, Huber C, Westhof E & Famulok M. Nucleic Acids Res. 25, 4018-4027. (PDF)

Stimulation of DNA inversion by FIS: evidence for enhancer-independent contacts with the Gin-gix complex (1997) Deufel A, Hermann T, Kahmann R & Muskhelishvili G. Nucleic Acids Res. 25, 3832-3839. (PDF)

Evidence for a hydroxide ion bridging two magnesium ions at the active site of the hammerhead ribozyme (1997) Hermann T, Auffinger P, Scott WG & Westhof E. Nucleic Acids Res. 25, 3421-3427. (PDF)

Conformational changes and spatial arrangement of the E. coli chaperones GroEL and GroES (1997) Stegmann R, Manakova E, Axmann S, Rossle M, Hermann T, May RP, Wiedenmann A, Pluckthun A & Heumann H. Physica B 234, 220-222.

A three-dimensional working model for a guide RNA from Trypanosoma brucei (1997) Hermann T, Schmid B, Heumann H & Goringer HU. Nucleic Acids Res. 25, 2311-2318. (PDF)

1996

Strained template under the thumbs: how reverse transcriptase of human immunodeficiency virus type 1 moves along its template (1996) Hermann T & Heumann H. Eur. J. Biochem. 242, 98-103. (PDF)

1995

Determination of nucleotide distances in RNA by means of copper phenanthroline-generated hydroxyl radical cleavage pattern (1995) Hermann T & Heumann H. RNA 1, 1009-1017. (PDF)

HIV-1 reverse transcriptase-associated RNase H cleaves RNA/RNA in arrested complexes: implications for the mechanism by which RNase H discriminates between RNA/RNA and RNA/DNA (1995) Gotte M, Fackler S, Hermann T, Perola E, Cellai L, Gross HJ, LeGrice SFJ & Heumann H. EMBO J. 14, 833-841. (PDF)

A combined ab initio and gas-phase electron diffraction investigation of the molecular structure and conformation of (silylmethyl)-cyclopropane (1995) Dakkouri M & Hermann T. J. Mol. Struct. 346, 239-248. (PDF)

1994

The 'helix clamp' in HIV-1 reverse transcriptase: a new nucleic acid binding motif common in nucleic acid polymerases (1994) Hermann T, Meier T, Gotte M & Heumann H. Nucleic Acids Res. 22, 4625-4633. (PDF)

1993

Hydroxyl radical footprint analysis of human immunodeficiency virus reverse transcriptase-template/primer complexes (1993) Metzger W, Hermann T, Schatz O, LeGrice SFJ & Heumann H. Proc. Natl. Acad. Sci. USA 90, 5909-5913. (PDF)

Spectra and structure of small ring compounds: IR and Raman spectra, vibrational assignment, conformational stability and ab initio calculations of cyclopropylmethylsilane (1993) Little TS, Zhu X, Wang A, Durig JR, Dakkouri M, Hermann T & Sala O. Spectrochim. Acta [A] 49, 1913-1933.

Reviews:

Small molecules targeting viral RNA (2016) Hermann T. Wiley Interdiscip. Rev. RNA. (PDF)

Non-coding RNA: Antibiotic tricks a switch (2015) Hermann T. Nature 526, 650-651. (PDF)

The DIY guide to RNA nanotechnology; book review on "Methods in Molecular Biology 1297: RNA Nanotechnology and Therapeutics: Methods and Protocols. Edited by Peixuan Guo and Farzin Haque" (2015) Hermann T. ChemBiochem, DOI: 10.1002/cbic.201500389. (PDF)

Hepatitis C virus translation inhibitors targeting the internal ribosome entry site (2014) Dibrov SM, Parsons J, Carnevali M, Zhou S, Rynearson KD, Ding K, Garcia Sega E, Brunn ND, Boerneke MA, Castaldi MP & Hermann T. J. Med. Chem. 57, 1694-1707. (PDF)

Aminoglycoside antibiotics: old drugs and new therapeutic approaches (2007) Hermann T. Cell. Mol. Life Sci., 64, 1841-1852. (PDF)

A-site model RNAs (2006) Hermann T. Biochimie 88, 1021-1026. (PDF)

Drugs targeting the ribosome (2005) Hermann T. Curr. Opin. Struct. Biol. 15, 355-366. (PDF)

RNA as a target for small-molecule therapeutics (2005) Hermann T & Tor Y. Expert Opin. Ther. Patents 15, 49-62. (PDF)

Chemical and functional diversity of small molecule ligands for RNA (2003) Hermann T. Biopolymers 70, 4-18. (PDF)

Rational ligand design for RNA: The role of static structure and conformational flexibility in target recognition (2002) Hermann T. Biochimie 84, 869-875. (PDF)

Strategies for the design of drugs targeting RNA and RNA-protein complexes (2000) Hermann T. Angew. Chem. Int. Ed. 39, 1890-1904. (PDF)

Rational drug design and high-throughput techniques for RNA targets (2000) Hermann T & Westhof E. Comb. Chem. High Throughput Screen. 3, 219-234. (PDF)

RNA bulges as architectural and recognition motifs (2000) Hermann T & Patel DJ. Structure 8, R47-R54. (PDF)

Adaptive recognition by nucleic acid aptamers (2000) Hermann T & Patel DJ. Science 287, 820-825. (PDF)

Stitching together RNA tertiary architectures (1999) Hermann T & Patel DJ. J. Mol. Biol. 294, 829-849. (PDF)

Non-Watson-Crick base pairs in RNA-protein recognition (1999) Hermann T & Westhof E. Chem. Biol. 6, R335-R343. (PDF)

Leadzyme RNA catalysis (1999) Westhof E & Hermann T. Nature Struct. Biol. 6, 208-209. (PDF)

Saccharide-RNA recognition (1998) Hermann T & Westhof E. Biopolymers 48, 155-165. (PDF)

RNA as a drug target: chemical, modelling, and evolutionary tools (1998) Hermann T & Westhof E. Curr. Opin. Biotechnol. 9, 66-73. (PDF)

Deciphering RNA recognition: aminoglycoside binding to the hammerhead ribozyme (1998) Tor Y, Hermann T & Westhof E. Chem. Biol. 5, R277-R283. (PDF)

The guide RNA database (1997) Souza AE, Hermann T & Goringer HU. Nucleic Acids Res. 25, 104-106. (PDF)

Book Chapters:

New strategies for docking cationic drugs to RNA targets (2000) Hermann T & Westhof E in: Schroeder R & Wallis MG (eds.) RNA-Binding Antibiotics, Landes Bioscience, Austin TX, pp.146-156.

Structure and distance determination in RNA with copper phenanthroline probing (2000) Hermann T & Heumann H. Methods Enzymol. 318, pp.33-43. (PDF)

Translocation of E. coli RNA polymerase during RNA synthesis (1997) Heumann H, Zaychikov E, Denissova L & Hermann T in: Eckstein F & Lilley DMJ (eds.) Nucleic Acids and Molecular Biology. Mechanisms of Transcription, Vol. 11, Springer, Berlin, pp.151-177.

Protein-DNA interface of the complex of T1 A1 promoter and DNA-dependent RNA polymerase from E.coli (1992) Heumann H, Schickor P, Hermann T, Palecek E & Metzger W in: Lilley DMJ, Heumann H & Suck D (eds.) Structural Tools for the Analysis of Protein-Nucleic Acid Complexes, Birkhauser, Basel, pp.223-240.

Patents:

Antiviral translation inhibitors (2011) Hermann T, Carnevali M. PCT US61/567,968.

Antiviral compounds for the treatment of HCV infection (2009) Hermann T, Carnevali M. WO 2009/099897 A1. (PDF)

Antibacterial 3,5-diaminopiperidine-substitute aromatic and heteroaromatic compounds (2007) Zhou Y, Vourloumis D, Gregor VE, Winters G, Hermann T, Ayida B, Sun Z, Murphy D, Simonsen KB. USP 7,223,759.

Antibacterial 3,5-diaminopiperidine-substitute aromatic and heteroaromatic compounds (2005) Zhou Y, Vourloumis D, Gregor VE, Winters G, Hermann T, Ayida B, Sun Z, Murphy D, Simonsen KB. WO 2005/028467 A1. (PDF)

Tri-substituted benzimidazoles and solid phase organic synthesis thereof (2002) Vourloumis D, Takahashi M & Hermann T. US Patent Serial No. 60/428,976, pending.